"Breakout" is a single from the Foo Fighters' third album There is Nothing Left to Lose. The single was released as a two disc set in the UK and Europe, and also had separate releases in the Netherlands, Australia and Japan. Promotional singles were also released in the United States for radio play.
The song appeared as a playable track in the music video game Lego Rock Band.
The video was directed by The Malloys that served as a tie-in to the song's appearance in the film Me, Myself & Irene. It mainly features Dave Grohl playing a character who has a "multiple personality" disorder (just like Jim Carrey's character) while taking his girlfriend to see the movie at a drive-in. In addition to Grohl's mom, Ginny, as the woman who flips him off while he is driving, the video also features some of the actors from the Me, Myself & Irene including Traylor Howard, who played his girlfriend, Tony Cox and Anthony Anderson. The MTV series Making the Video documented the making of the music video.